Multiple Sclerosis

MULTIPLE SCLEROSIS

Multiple Sclerosis

Multiple Sclerosis: Recognizing Multiple Sclerosis

Multiple sclerosis symptoms generally appear between the ages of 20 and 40. 

Common and Uncommon Symptoms of MS (Multiple sclerosis).

The most common early symptoms of MS include:

  • Tingling
  • Numbness
  • Loss of balance
  • Weakness in one or more limbs
  • Blurred or double vision

Less common symptoms of MS may include:

  • Slurred speech
  • Sudden onset of paralysis
  • Lack of coordination
  • Cognitive difficulties

As the disease progresses, other symptoms may include muscle spasms, sensitivity to heat, fatigue, changes in thinking or perception, and sexual disturbances.

 

Compounding for Multiple Sclerosis

Medication  option No.1:4-AP (4-AMINOPYRIDINE)

4-Aminopyridine (4-AP) is a drug shown to improve visual function and motor skills and relieve fatigue in patients with Multiple Sclerosis (MS). 4-AP is most effective in patients with the chronic progressive form of MS, in patients who are temperature sensitive, and in patients who have had ms for longer than three years. Common side effects include dizziness, nervousness and nausea, and the incidence of adverse effects was shown to be less than 5% in all studies.

4-AP works as a potassium channel blocker. Electrophysiologic studies of demyelinated axons show that abnormal potassium currents decrease action potential duration and amplitude and contribute to conduction failure. Potassium channel blockade prolongs the repolarization phase of the action potential, increasing conductivity along the demyelinated axon.

4-AP works as a potassium channel blocker. Electrophysiologic studies of demyelinated axons show that abnormal potassium currents decrease action potential duration and amplitude and contribute to conduction failure. Potassium channel blockade prolongs the repolarization phase of the action potential, increasing conductivity along the demyelinated axon.

MS patients treated with 4-AP exhibited a response rate of 29.5% to 80%. A long-term study (32 months) indicated that 80-90% of patients who initially responded to 4-AP exhibited long-term benefits. Although improving symptoms, 4-AP does not inhibit progression of MS.

Spinal cord injury patients have also seen improvement with 4-AP therapy. These improvements include sensory, motor and pulmonary function, with a decrease in spasticity and pain.

AMINOPYRIDINE (4-AP) Clinical Neuropharmacology, Vol. 16, pp. 195-204 .

We compound 4-Amino Pyridine capsules call for information!  Yes we ship!

 Please click on the link below to download the Physician’s prescription order form.  Thank you for giving us the opportunity to serve you!

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Medication option No. 2:Low Dose Naltrexone (LDN)

Naltrexone is a pure opiate antagonist that has been used for years as part of heroin withdrawal programs. When given to humans in low doses, naltrexone increases the body’s production of endorphins. Endorphins are hormones, produced by the body, which help maintain and regulate the immune system. Patients with multiple sclerosis (MS), and other immune disorders, have lower measured levels of endorphins than healthy patients. It is thought that the lower levels of endorphins cause some immune systems cells to malfunction and begin attacking the body’s nervous system. In MS patients, the myelin that insulates nerve fibers is attacked leading to the development of scars (or plaque) in the brain and spinal cord and corresponding neuropathic symptoms. There is current research taking place in the United States looking at the ability of low dose naltrexone (LDN) to stimulate the body’s production of endorphins, which may help alleviate some symptoms that MS patients experience. By helping to bolster the immune system, low dose naltrexone is also showing encouraging results in other diseases such as certain types of cancer and HIV infection.

Patients taking low-dose naltrexone report decreased progression in their disease with fewer exacerbations, relief of arm pain, improved bladder control, reduction in fatigue, reduction in numbness in lower legs and feet, reduction in stiffness and muscle spasms, reduction in dizziness and slurred speech.

SMCC prepares immediate-release naltrexone capsules in both 1mg, 3mg and 4.5mg dosages. The recommended dosage is one capsule taken at bedtime.

 

In order to adequately evaluate the effectiveness of LDN, patients should use the medication for a minimum of 3-months.

Physicians Click Link Below for Form

Please click on the link above to download our prescription order form for your physician’s use.  We look forward to serving you.

Multiple Sclerosis FAQ’S